“Significant blood line”

Here is the verified answer to the Wall Street Journal Crossword clue “Significant blood line”, last seen on May 8, 2026.

Answer hidden — reveal below

A???A

A 5-letter down entry from the Friday puzzle

The Answer

AORTA

The answer to “Significant blood line” is AORTA

Letters5

DirectionDown

PublishedMay 8, 2026

Letter analysis

The clue “Significant blood line” appeared in the Wall Street Journal Crossword on Friday, May 8, 2026 as a down entry. The verified answer is AORTA — a 5-letter word that begins with A and ends with A.

This answer contains 3 vowels and 2 consonants. Click through any related clue below to keep solving, or open the full answer key for the day from the link above.

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Frequently Asked Questions

What is the answer to “Significant blood line”?

The answer to the Wall Street Journal Crossword clue “Significant blood line” is AORTA — a 5-letter down entry from the May 8, 2026 puzzle.

How many letters is the answer?

AORTA has 5 letters — 3 vowels and 2 consonants.

Are these answers official?

WSJCrosswordAnswers.org is an independent reference site, not affiliated with the Wall Street Journal. We solve and verify each puzzle by hand before publishing.